Minimal floor space difference - in Row 1 it feels like your snout is pressed up against the bulk head for takeoff and landing:
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Well it does to me - again personal opinion
If travelling as couple I always stick the Ette in 1F and moi in 2 F - replicates side of bed we sleep on at home - if solo makes no never mind - any other Suite than Row 1 for me
And at the risk of sounding like a broken record all 6 new R are pox compared to 3C in old R - my home away from home 
