Lets say you are at flying out of JFK, plane has pushed back, now you are in queue for departure ...... unfortunately for whatever reasons there is a huge backlog of departing flights and now you're queued up, behind 42 other planes to take off before you are. And all of a sudden, you have an urge to go to the bathroom (for whatever reasons as well) and you just can't hold it anymore ... I mean, the 43rd plane in line to take off, can take say at least an hour in line ..... so what do you as a pilot do? Have a quick run to the toilet whilst the FO takes over? And how about the passengers, when nature calls, it just calls. I mean it can get very uncomfortable