Your post got me thinking of the differences between flying the A380 and 747 200. The 747 must be very manual when compared to the a380. So what automations has made the job easer /safer for the pilot and did any changes make it harder?
Even though there is a lot of time between the 747-200/300 and the A380, I'm not sure that the differences are as great as you'd imagine.
I moved from the FO seat on the Classic 747 to the 747-400 in 1990. At that point the -400 was brand new, and in large part the training simply taught you how to convert it back into a -300. If you got confused, taking it back one step put you back in familiar territory. It was, in almost all ways, a huge leap forward, even though the majority of the changes were within the coughpit. The glass displays were logical, and easy to read. The workload actually increased in many ways though, as system management that had previously been the FEO's job was now given a touch of automation and dumped on to the pilots. Like so many things, it was easier when things were going well, but much harder when they weren't.
The biggest improvement of all though, was the autopilot. It became much more accurate. If you selected -400 fpm in vertical speed mode, that was exactly what you got. Previously it would be somewhere near that. Making it exact meant that many non precision approaches could now be flown via manipulation of the autopilot, instead of manually flying. It was easier, but more importantly, more accurate.
Going to the 767 after the -400 was a bit of a step backwards. The coughpit was Boeing's first attempt at a glass coughpit, and it still included some analogue displays. They mostly disappeared over the years. But, the 767 did have the better autopilot (and I guess got it first). My original plan when going to the -400 as an FO had been to come back to the Classic for a command, but when the time came, I preferred to stay with the glass jet, which is why I went 767.
Moving back to the -400 after the 767 was straightforward. It was described by the 744 fleet manager (who was also ex-767) as simply being a 767 in slow motion. Not far wrong.
The A380 was a very different kettle of fish; mostly because it was extremely procedurally driven. That was actually softened over the years, as it became evident that the people who wrote the procedures hadn't really thought of everything. The A380 does many things very well, but there are actually some autopilot modes that the old aircraft has, that it doesn't. For instance, it won't automatically fly a VOR radial, though of course, there are ways around that.
You need to consider what you mean by automation. None of the aircraft make decisions by themselves.
Automation has made day to day ops, when everything is working, much easier. Conversely, it has made abnormal ops, when things are going wrong, appreciably more difficult.