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I stopped using TAs in 1994 (yes pre-internet) as the journey maker/acquirer. I found even in those days that I could book flights for work (40+ rtn domestic yrly), accommodation etc at around 40-50% the cost charged (at the worst that is) and GET THE TIMES I WANTED. At first the senior mgmt (& HR of one of the 4 Banks) made it clear that although I was strictly not breaking any rules that they did not like it. Precedents are never liked in bureaucracies I suppose.
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Modern times - since then I've used TAs as an error check and wholesaler access service. Provided there are sufficient seats available (on a itinerary I have created) I then call 2 or 3 to alert them to my incoming email with the Matrix booking codes, give them 30 minutes (easy I) or an hour (more involved I) and am totally upfront with them:
I can book this right now for $XCCC, I have emailed it to 2 other TAs and I would like you to get back to me by 10.30am with your one and only so make it your best offer please. I will not take a revised better offer as it is not fair to the other TAs.
If I had never been to a destination in a developing country then perhaps I would select one of them as the journeyman (only if AFF failed me I suppose).
I think having a good relationship with a good TA (the person, not his/her firm) is a tremendous asset.