You have stated one level of facts, but other level of facts would include:
- when did X reach Y% of vaccination? I think Israel reached most vaccination levels earlier and there has been some evidence of protection waning.
- do both have similar lockdown, social distancing (eg masks, density) and border restrictions?
- what proportion of cases are in vaccinated and unvaccinated?
- the mix of Pfizer v other vaccines in the community?
- deaths is a lagging indicator usually.
I'm sure there are possibly other factors.
Similiar vaccination rates.similiar relaxation of
restrictions.The one big difference is the UK used AZ and Israel did
not.That said the UK has given more Pfizer shots than Israel.
So the possibilities are the decrease in effectiveness of the Pfizer vaccine after 6 months or the short time between doses 1 and 2 in Israel.
A couple of interesting articles that have come out this
week.First from San Diego re breakthrough infections in
HCW.All vaccinations were
mRNA.By March 76% had been vaccinated and by July 83%.The effectiveness of the vaccinations was ~ 90% until June but fell to 65.5% in July.
Interesting looking at attack
rates.Those who were vaccinated in January or February had a positive rate of 6.7 per 1000.For vaccinations between March and May 3.7.For unvaccinated staff the rate was 16.4.
Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.
www.coronavirustoday.com
And in the Lancet a very interesting study in the UK and AZ vaccination results.Several findings.
We also report the persistence of antibody and cellular responses at 182 days and for antibodies up to 320 days after first dose of ChAdOx1 nCoV-19.
It also found that the longer the time before a second dose was given the greater the antibody response was to that second
dose.They gave the second dose up to 45 weeks after the first.
Antibody levels induced by a single dose of ChAdOx1 nCoV-19 decreased gradually but remained above baseline levels after 1 year. We have previously shown that administration of a second dose of vaccine induces higher antibody responses by 1 month after the second dose than before the second dose, with higher responses with a dose interval up to 3 months between the first two doses.
3
Here, we found that a long extension of the dose interval (up to 45 weeks) between the first and second dose further enhances the immune response to the second dose when compared with shorter dose intervals. Furthermore, for the first time, we showed that a third dose of ChAdOx1 nCoV-19 can induce a strong boost to immune responses to the transgene product, SARS-CoV-2 spike protein, and that these responses result in increased neutralising antibody titres and enhanced antibody activity against variants.
A third dose was given to some 28-38 weeks after the second
dose.The results were better than after the second dose.
Here, we show that a third dose of ChAdOx1 nCoV-19 is well tolerated and significantly boosts antibody titres above those measured after the second dose to the level associated with 80% vaccine efficacy, or higher, after two vaccine doses (unpublished; preprint data available.
Higher titre neutralising antibodies against alpha, beta, and delta variants of SARS-CoV-2 were induced 28 days after a third dose vaccination than after the second dose.
An extended interval before the second dose of ChAdOx1 nCoV-19 leads to increased antibody titres. A third dose of ChAdOx1 nCoV-19 induces antibodies to a level that correlates with high efficacy after second dose and boosts T-cell responses.
www.thelancet.com
So it is possible that those who have been waiting after their first dose of AZ are well advised to now go and have their second dose of AZ as the results likely to be better than having Pfizer as the second jab.
As well side effects were much less after the second and third
doses.VITT is extremely rare after the second dose - ~ 1 in 3.5million.
It is possible those that have Pfizer will need a booster at 6 months but with AZ possibly at 12 months.