No, not really. I suppose if you were light enough, and the good engine was inboard, you might be able to get away with something. The power required on approach would be around 100%.
It flies pretty well on two, but you wouldn’t want that to happen on take off. We did play with that (one on the take off roll, and the second airborne) in the sim, but you need to be able to trade some height for speed to allow you to accelerate and clean up. If you don’t have any height to trade, you’ll never get above the drag hump, and the speed will slowly bleed, with an obvious end result. The performance in this instance was quite a bit better than the 747 though.