Yes, I did PER-SIN-SEA back in March with an overnight at YOTELAIR Changi. Bag at Perth was checked all the way through to US leaving the next morning. Just put things I needed overnight into my carry-on.
Coming back flew SFO-SIN-PER with two nights again at Changi. Checking in at SFO the person was originally going to check my bag all the way through to PER. Since I had two nights in SIN I requested they only check it to SIN. Interestingly, the check-in staff had to get a supervisor to assist as she didn't know how to only check the bag to first stop.
All baggage check-in went smoothly in both directions. As you're packing, just consider what you will need in-transit and remember the 100ml liquids rules. In a previous trip through SIN I accidentally had a 150ml lotion container in carry-on but it was only about half full. The co-operative security staff actually provided an empty 100ml plastic bottle for me to use so that I was within limits and could still carry the lotion.