Russia has closed its airspace to most countries which have been supporting Ukraine. Australia hasn't been banned, but Qantas has opted not to route via Russian airspace.
Ukraine airspace has been closed since Feb 2022 due to Russia's invasion. Airspace in Moldova near the Ukraine border is also closed due to Russia.
The Simferopol FIR (Crimea), which controls half the Black Sea, has been closed since 2014 due to both Russia and Ukraine attempting to control that airspace.
Syria is under do not fly listings from the US, UK, Canada, Germany, Italy and France.
Yeman is also under do not fly listings by the above, with some allowances for oceanic routes within Yeman controlled airspace.
Iraq has warned of GPS jamming in the north. US, UK, Canada, Germany, Italy and France have again listed the the Baghdad FIR as do not enter, again with some allowance to fly above FL320. (Germany says FL280 and South Africa says FL300)
US, UK, Germany, and Canada are also saying not to enter Tehran FIR (Iran). US also says to be careful around the Persian Gulf and Gulf of Oman. France says not to fly over western Iran, Eastern Iran over FL320. Italy says don't fly in Iran below FL320.
There are also similar warnings for airspace in Egypt, Sudan and Libya.
If things get worse around the middle east, even the current QF1/2/9/10 routes might have problems.