Some data points here: my partner is an Italian national and thus eligible for ESTA. I'm Canadian with Nexus (Global Entry). We had to transit through 1 airport (JFK) and pre-clear another (YVR for our flight to SFO). In both instances my partner actually got through slightly quicker than I did with Global Entry. With that being said, I still prefer Global Entry over MPC (which I'm also eligible to use) for the simple fact that I don't need to fill anything out. The process of Global Entry is, you walk up to a kiosk, it scans your face, and then you wait for an officer to call your name. They usually ask what is the purpose of your trip and that's it. No need for a passport or WHTI compliant document to pass enter the US (technically you still need to have those on hand but in practice it's all touch free).
-RooFlyer88