Will you vaccinate with Conoravirus vaccine when one is available?

[CityRail]

According to reports, coronavirus vaccine is entering its final phase of testing and very soon we will have millions of coronavirus vaccine to be rolled out, hopefully from September.

By then, should a coronavirus vaccine is available, will you vaccinate it?

Personally speaking, as a 30 year old young person, I will not vaccinate myself with Coronavirus, because:

1. It is just a small flu for young people, we won't die;
2. The vaccine is rushed and I cannot guarantee if I vaccinate myself, I will be immune to Coronavirus and not get killed by the vaccine;
3. The coronavirus vaccine is just a step to reopen our borders so that we can travel overseas again.

I am not anti-vaxier, however I only think that Coronavirus vaccine is just a political ticket for politicians to explain to the public that they can now open the international borders again and ease off travel bubbles.

What do you think?

 

[HappyFlyerFamily]

Why is it conditional approval? I’m guessing not the same as either emergency use or full approval

 

[Lynda2475]

2 year validity subject to Pfizer continuing to share international data.

From SMH:

The Pfizer vaccine comes with minor but common side effects, the TGA’s release documentation states.

More than 60 per cent of who get a jab will experience fatigue, more than 50 per cent will get a headache, more than 30 per cent will get muscle pain or chills and more than 20 per cent will have joint pain.

Most of these effects dissipate a few days after vaccination. Young people seem slightly more likely to have side effects compared with the elderly.

Importantly, scientists say these side effects are evidence the vaccine is working – generating a powerful immune response to an invader, just like a cold or the flu.

The TGA on Monday granted provisional approval for the Pfizer vaccine to be administered to Australians, and the rollout is due to start in late February.

Two people in Britain suffered anaphylactic shock after the vaccine; both had a history of severe allergic reactions, and both have since recovered.

Data from the vaccine rollout suggests about 11.1 people in every million given the vaccine will experience anaphylaxis. In light of that, the TGA is asking doctors to closely watch people for at least 15 minutes after injection.

So far, the vaccine trials have tracked participants for only two months. However, the TGA’s vaccine experts believe nearly all serious vaccine side effects should show up after four weeks, so they are confident the vaccine has an acceptable level of safety.

Before the vaccine is released to health professionals, it will undergo batch testing at the TGA’s laboratories to check quality control.

 

[auriga]

.....

For the very frail – people aged over 85 – the TGA recommends doctors vaccinate on a “case by case basis”, as the potential benefits of the vaccine must be weighed against the risks of exposing a very frail person to the vaccine’s standard flu-like side-effects.

Maybe I have got this wrong, I thought one of things to do was to make sure the most vulnerable people are protected. If they are not vaccinating the over 85's, then how can we expect them to loosen restrictions/borders?

 

[Lynda2475]

Maybe I have got this wrong, I thought one of things to do was to make sure the most vulnerable people are protected. If they are not vaccinating the over 85's, then how can we expect them to loosen restrictions/borders?

Some treating doctors may wait to see more data from overseas roll-out to decide whether to vaccinate those with serious existing conditions and which vaccine may be best for that age group.

I think any loosening of international restrictions will be dependent on vaccines being widely rolled out, at least 6 months away.

 

[auriga]

Some treating doctors may wait to see more data from overseas roll-out to decide whether to vaccinate those with serious existing conditions and which vaccine may be best for that age group.

I think any loosening of international restrictions will be dependent on vaccines being widely rolled out, at least 6 months away.

in other words, wait, wait and wait some more!

 

[HappyFlyerFamily]

And keep shielding/isolating vulnerable for some time.

Hopefully Australia’s main vaccine Oxford Astra Zeneca fares better

 

[Pushka]

Maybe I have got this wrong, I thought one of things to do was to make sure the most vulnerable people are protected. If they are not vaccinating the over 85's, then how can we expect them to loosen restrictions/borders?

I think they are just saying that if people are aged over 85 then an additional assessment may be needed and a more thorough benefit versus risk profile be developed on an individual basis. Eg other significant medical issues.

 

[tomlee1986]

Why is it conditional approval? I’m guessing not the same as either emergency use or full approval

I think conditional on the batch test of the product

 

[Pushka]

From a GP visit this morning, it seems there is investigation of risks of people on methotrexate and plaquenil (hydroxychloroquine) and other immune suppressants to receive Astra Zeneca vaccine and possibly can only receive Pfizer and Moderna.

 

[drron]

Except the Pfizer and Moderna vaccines basically haven't been tested on immune compromised patients.
And the Astra vaccine although an attenuated virus has been rendered replication deficient.

AstraZeneca COVID-19 vaccine uses a replication deficient chimpanzee adenovirus (ChAd) as
a vector to deliver the full-length SARS-CoV2 spike protein genetic sequence into the host cell
(Van Doremalen et al, 2020). The adenovirus vector is grown in a human cell-line (HEK293)
(see chapter 1). ChAd is a non-enveloped virus, and the glycoprotein antigen is not present in
the vector, but is only expressed once the genetic code within the vector enters the target
cells. The vector genes are also modified to render the virus replication incompetent, and to
enhance immunogenicity (Garafalo et al, 2020). Once the vector is in the nucleus, mRNA
encoding the spike protein is produced that then enters the cytoplasm. This then leads to
translation of the target protein which acts as an intracellular antigen.

Also the UK has given emergency autorisation to the Oxford vaccine and UK groups suggest the Oxford vaccine is safe in immunocompromised patients.

• Page 14 of the Green Book on the official gov.uk website states that "Although [Oxford] AstraZeneca COVID-19 vaccine contains a live adenovirus vector, this virus is not replicating and is considered safe in immunosuppressed people." The Green Book has the latest information on vaccines and vaccination procedures for vaccine preventable infectious diseases in the UK.

• Public Health England's guidance for healthcare professionals does not list immunosuppression as a reason not to have any of the vaccines.

• The British Society for Immunology state that "All three of the COVID-19 vaccines (Pfizer/BioNTech; AstraZeneca/Oxford; Moderna) that have currently been approved for use in the UK are safe to use for people who are immunocompromised or immunosuppressed."

• The British Society of Gastroenterology state that "We strongly support SARS-CoV2 vaccination for patients with IBD. We recommend that IBD patients accept whichever approved SARS-CoV2 vaccination is offered to them.

Latest: Coronavirus vaccine for people with Crohn’s or Colitis | Crohn's & Colitis UK

www.crohnsandcolitis.org.uk

But also remember immuno compromised may only develope 20-30% of the immune response as immuno competent patients.

Also the Oxford group has started trials in patients over 55 and in HIV positive patients.Pfizer and moderna as far as I know are not doing this.

 

[OZDUCK]

After I posted my question a 'senior' member of the government said it is still on track - but --- -

Vaccine rollout on schedule despite Pfizer shortages, Treasurer says

Josh Frydenberg says Pfizer/BioNTech vaccine shortages overseas are unlikely to affect Australia's planned COVID-19 vaccine rollout, with vaccinations still scheduled to arrive next month.

www.abc.net.au

I think the Govt. has been unduly optimistic about vaccine supplies in the last few days. Europe is almost certainly heading towards export restrictions and I believe our first doses are due to come from there. The local production of the 'Oxford' vaccine is not due to produce significant amounts until later this year. I remember the Govt. putting out big press releases last year about building facilities to produce the other types of vaccines but I have not heard or seen anything since then. I gather it will be a big lead time to get the necessary equipment as a number of countries will be trying to buy it.

Coronavirus: Vaccine supply fears grow amid EU export threat

The EU calls for "fair" distribution after vaccine companies cut back on pledged supplies.

www.bbc.com

 

[Pushka]

Except the Pfizer and Moderna vaccines basically haven't been tested on immune compromised patients.
And the Astra vaccine although an attenuated virus has been rendered replication deficient.


Also the UK has given emergency autorisation to the Oxford vaccine and UK groups suggest the Oxford vaccine is safe in immunocompromised patients.

Latest: Coronavirus vaccine for people with Crohn’s or Colitis | Crohn's & Colitis UK

www.crohnsandcolitis.org.uk

But also remember immuno compromised may only develope 20-30% of the immune response as immuno competent patients.

Also the Oxford group has started trials in patients over 55 and in HIV positive patients.Pfizer and moderna as far as I know are not doing this.

Knowing the way I continue to develop varieties of antibodies to me, even on plaquenil, I'd hope I would do the same thing to pesky foreign ones. I think I just want the certificate of vaccination and not worry about the rest

 

[Pushka]

Except the Pfizer and Moderna vaccines basically haven't been tested on immune compromised patients.
And the Astra vaccine although an attenuated virus has been rendered replication deficient.


Also the UK has given emergency autorisation to the Oxford vaccine and UK groups suggest the Oxford vaccine is safe in immunocompromised patients.

Latest: Coronavirus vaccine for people with Crohn’s or Colitis | Crohn's & Colitis UK

www.crohnsandcolitis.org.uk

But also remember immuno compromised may only develope 20-30% of the immune response as immuno competent patients.

Also the Oxford group has started trials in patients over 55 and in HIV positive patients.Pfizer and moderna as far as I know are not doing this.

So it's the fact it was a live virus that is the issue? But not a truly live one. GP also mentioned the shingles one would likely be a no-go. She is conferring with the rheumatologist but not due for that yet. Phew. Thanks!

 

[PineappleSkip]

Interesting infographic about rapidly increasing global enthusiasm for getting a COVID vaccine, with LOTFAP and South Africa bucking the trend.
Sorry, Australia was not polled it seems
Increase In Global Covid-19 Vaccine Enthusiasm

a recent Ipsos MORI poll found that vaccine hesitancy is now transitioning into a global stampede for access

Never underestimate the power of ,loss aversion to render people - and governments - dumb and dumber, especially when the rush makes the scarcity a self-fulfilling prophecy. Not hard to see COVID shots becoming the new toilet paper.

Cheers skip

 

[drron]

The technology is really amazing.Now animal studies into nanoparticles which could produce a vaccine against multiple viruses.Successfully tested in mice so far.

Nanoparticle Technology Holds Promise for Protecting Against Many Coronavirus Strains at Once

It’s truly encouraging to witness people all across our nation rolling up their sleeves to get their COVID-19 vaccines. That is our best chance to end this pandemic. But this is the third corona-vi…

directorsblog.nih.gov

 

[AisleSeat]

My friend in the US getting the second shot of the Moderna one today and my mum is getting the first shot of the Oxford Zeneca one next week.

 

[jakeseven7]

Support for vaccine grows as four in five Australians say they are willing to be vaccinated​

​

The number of Australians who say they are willing to be vaccinated against COVID-19 has increased during January, as the country prepares for its vaccine rollout.

Seventy-nine per cent of adults said they were willing to be vaccinated in a Roy Morgan survey conducted on Wednesday and Thursday last week, up 2 per cent from the previous week.

Men were more likely than women to say they will be vaccinated when the vaccine becomes publicly available, with 85 per cent expressing this view (up four percentage points). Women expressed willingness at the same rate as the previous week (73 per cent).

As it happened: Qld border to reopen to Greater Sydney as Gladys Berejiklian eases NSW restrictions; Australia ranked eighth for COVID-19 response

New research shows Australia is in the top-10 countries in handling the pandemic and disproved a claim authoritarian regimes had an advantage.

www.theage.com.au

 

[Must...Fly!]

Germany questions efficacy of AstraZeneca vaccine in the elderly

Germany's vaccine committee tells the nation's health ministry the AstraZeneca vaccine should not be given to the elderly due to "insufficient data", a claim that British Prime Minister Boris Johnson has since contested.

www.abc.net.au

The rather odd attitude toward the Oxford vaccine continues. At least in media - it is the right of the authorities to outline such issues.

 

[OZDUCK]

Some more news on the vaccination front -:

Morrison says Australia has secured another 10 million doses of the Pfizer vaccine​

Prime Minister Scott Morrison has announced that Australia has secured more of the Pfizer vaccine.

Federal Health Minister Greg Hunt gave a rundown of the now 150 million doses of vaccines Australia has now bought:

• 53.8 million Oxford AstraZenica
• 20 million Pfizer
• 51 million Novavax
• 25.5 million under the COVAX agreement

And

There is no plan for Australians to 'choose' which vaccine they receive​

Professor Murphy says the Pfizer vaccine will be prioritised for higher-risk populations such as frontline workers and those residing or working in aged and disability care facilities. These will be distributed in Pfizer-specific facilities.

"The majority of the population on our plan will have access to the AstraZeneca vaccines, which will be run in a much larger number of clinics, through GPs, eventually pharmacies, other state-run clinics. So, in the main, there won't be a choice, and I think both vaccines are extremely good, and I would be very happy to have either of them," Prof Murphy said.

 

[tgh]

There is continuing "resistance" in Europe to vaccinating the oldies with the Oaz vaccine, Suisse has banned it altogether pending more information.
The public reasons seem a tad lightweight , perhaps there is more to the story.
To this end it is easy to link the purchase of an extra 10m of Pf vaccine to an ongoing Oaz issue.