I had to cancel Kamchatka, Chad, Romania, Moldova, Ukraine, Azerbaijan, Armenia, Georgia in 2020.
With the current situation in E Europe, not much chance of ever getting to many of those.
One region of the world that is a substantial hole for me and that was in my dreams is West Africa.
The problem with going to slightly off-grid places with advancing age and the lingering spectre of Covid is getting travel insurance, at least at a reasonable price.
I'm sticking with domestic travel and not even thinking about anywhere overseas for the time being.