So the flights are booked, what parts should we avoid when booking accommodation, and I am not meaning Times Square as will be simply play tourist and depart. Budget is up to US 250 per night, obviously less is better. At the moment looking at Hilton in Edgewater, aware there are travel costs into the city but price is reasonable.Thanks for all your feedback it has been great.
In my opinion, there are not too many areas to avoid, as a blanket veto, in NYC. Wherever you stay, you will have a different experience, as you will tend to walk the immediate neighbourhood, even if you then take public transport to other localities for specific sites and activities.
For me, that's one of the great attractions of the city - that it is really a "city of cities".
On previous visits, we've stayed in many different sectors, including Upper Westside, Upper Eastside, Murray Hill, Midtown, various parts of Chelsea and the Village, across the river in NJ, and in Harlem, plus others I've probably forgotten for the moment. Many of those stays have been in rental apartments, some in the equivalent of B&Bs, a few in hotels.
Last week, we had an all-too-brief stay (3 nights) on the LES (Lower East Side), which we really enjoyed. A new hotel, which is a bit above your price range, so won't suit you for this trip, but I certainly would not recommend avoiding that part of town. It is full of interesting sights, sounds and flavours. Harlem, on a previous stay, was a great experience in a brilliant apartment, and there, too, we saw sites (and sights!) that we would have missed had we stayed downtown.
So perhaps look at the things you really want to do in your time in NYC, then focus on one of the localities that makes sense for those. You can then pick one of your target sites and do a web search on "Hotels near ....(MoMa/the Metropolitan/Madison Square/Times Square - or whatever takes your fancy)". The search will throw up hotels in all price brackets and makes a useful starting point for a more focused search.
Have fun planning.