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I think the initial response will be mandatory hotel quarantine for returning travellers from Southern Africa and a “Do not travel” for outbound.Hopefully in a few weeks or so the evidence will indicate that the new variant isn't something to be overly concerned about, but at this point we don't know and it's understandable that many nations are taking a cautious approach to this.
Worst case is we're back to square one and the vaccine manufacturers need to quickly develop a new version of the vaccine to target the new variant, and major restrictions on international travel come back.